The study was performed on healthy Iranian subjects who live in urban areas … Trabecular bone score (TBS) is a newly developed index for assessing trabecular bone quality and fracture risk. Khosla S , Melton LJ , Wermers RA , Crowson CS , O'Fallon W , Riggs B. Vignali E , Viccica G , Diacinti D , et al. Data are means ± SEM. Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by hypercalcemia and elevated or inappropriately normal levels of PTH. TBS is related to bone microarchitecture and provides skeletal information that is not captured from the standard bone mineral density (BMD) measurement. Trabecular bone score (TBS), as a tool for measurement of bone microarchitecture, represents fracture risk independently of bone density. A Spanish case-control study, Bone mineral density (BMD) combined with the trabecular bone score (TBS) significantly improves the identification of women at high risk of fracture: the SEMOF Cohort Study [abstract], Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study, Trabecular bone score improves fracture risk prediction in non-osteoporotic women: the OFELY study, What is the performance in vertebral fracture discrimination by bone mineral density (BMD), micro-architecture estimation (TBS), body mass index (BMI) and FRAX in stand-alone or combined approaches: The OsteoLaus Study [abstract], Spine micro-architecture estimation (TBS) discriminates major osteoporotic fracture from controls equally well than site matched BMD and independently: the Eastern Europe TBS study [abstract], In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography, Comparison of 2D and 3D bone microarchitecture evaluation at the femoral neck, among postmenopausal women with hip fracture or hip osteoarthritis, Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment, High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone, Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method, Primary hyperparathyroidism: iliac crest trabecular bone volume, structure, remodeling, and balance evaluated by histomorphometric methods, Preserved three-dimensional cancellous bone structure in mild primary hyperparathyroidism, Bone structure in postmenopausal hyperparathyroid, osteoporotic, and normal women, Maintenance of cancellous bone connectivity in primary hyperparathyroidism: trabecular strut analysis, The histomorphometry of bone in primary hyperparathyroidism: preservation of cancellous bone structure, Assessment of trabecular and cortical architecture and mechanical competence of bone by high-resolution peripheral computed tomography: comparison with transiliac bone biopsy, Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality, Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women, Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures, Identification of rheumatoid arthritis patients with vertebral fractures using bone mineral density and trabecular bone score, TBS (trabecular bone score) and diabetes-related fracture risk, Bone quality, as measured by trabecular bone score in patients with adrenal incidentalomas with and without subclinical hypercortisolism, Effects of zoledronate versus placebo on spine bone mineral density (BMD) and microarchitecture assessed by the trabecular bone score (TBS) in postmenopausal women with osteoporosis. Trabecular bone score (TBS) is a texture index derived from standard lumbar spine dual energy X-ray absorptiometry (DXA) images and provides information about the underlying bone independent of the bone mineral density (BMD). Trabecular bone score (TBS) is a texture index derived from standard lumbar spine dual energy X-ray absorptiometry (DXA) images and provides information about the underlying bone independent of the bone mineral density (BMD). The Parathyroid Epidemiology and Audit Research Study (PEARS), Fractures in patients with primary hyperparathyroidism: nationwide follow-up study of 1201 patients, Correlations between grey-level variations in 2D projection images (TBS) and 3D microarchitecture: applications in the study of human trabecular bone microarchitecture, Correlations between trabecular bone score, measured using anteroposterior dual-energy X-ray absorptiometry acquisition, and 3-dimensional parameters of bone microarchitecture: an experimental study on human cadaver vertebrae, The predictive value of trabecular bone score (TBS) on whole lumbar vertebrae mechanics: an ex-vivo study [published online March 2013], Evaluation of the potential use of trabecular bone score to complement bone mineral density in the diagnosis of osteoporosis: a preliminary spine BMD-matched, case-control study, A multicentre, retrospective case-control study assessing the role of trabecular bone score (TBS) in menopausal Caucasian women with low areal bone mineral density (BMDa): analysing the odds of vertebral fracture, A retrospective case-control study assessing the role of trabecular bone score in postmenopausal Caucasian women with osteopenia: analyzing the odds of vertebral fracture, Is bone microarchitecture status of the lumbar spine assessed by TBS related to femoral neck fracture? Epub 2020 May 22. In fact, when TBS, aBMD, and measurements of trabecular microstructure by μCT were assessed at the same bony region, correlations of aBMD and TBS with BV/TV, Tb.N, Tb.Sp, and connectivity density were similar (13). The association between systemic bone loss and periodontitis remains unresolved; and the trabecular bone score (TBS) is a new index for assessing decreased bone quality. Likewise, Romagnoli et al (42) recently showed that TBS values were lower in subjects with mild PHPT than in aged-matched healthy control subjects, despite similar lumbar spine aBMDs by DXA (42). In clinical studies, TBS enhanced the ability of DXA to predict fracture risk (15–20), and in a recent study involving more than 29,000 postmenopausal women, TBS predicted osteoporotic fractures, independent of aBMD (20). Whole bone stiffness was defined as the reaction force divided by the applied displacement. Stein EM , Liu XS , Nickolas TL , et al. Correlations adjusted for body weight between TBS and trabecular number (A and C) and whole bone stiffness (B and D) at the radius/tibia. References. Quant Imaging Med Surg. With these developments, TBS has emerged as a clinical tool for improved fracture risk prediction and guiding decisions regarding treatment initiation, particularly for patients with FRAX probabilities around an intervention threshold. . Similarly, in the study of Boutroy et al (21), nonosteoporotic women whose TBS values were less than 1.209 (the first TBS quartile threshold) had a significant higher incidence of fragility fracture. Using cutoff points previously reported as having the best sensitivity and specificity in terms of fracture risk (19–23), we showed that 36% of patients with PHPT had degraded microarchitecture (TBS ≤1.20), an additional 36% had partially degraded microarchitecture (TBS >1.20 and <1.35), and only 27% had normal TBS values (TBS ≥1.35). Baseline characteristics of 22 postmenopausal women with PHPT are described in Table 1. Chinese expert consensus on the diagnosis of osteoporosis by imaging and bone mineral density. Results on Trabecular Bone Score (TBS) in these patients are lacking. Eight hundred and five Thai participants, aged 30 to 82 years, underwent bone quality assessment. It is a texture measurement that quantifies local variations in gray level distribution from dual-energy X-ray Absorptiometry (DXA) and is significantly correlated with three dimensional parameters of bone microarchitecture, independently of aBMD , , , . Results: Low BMD was detected in 19.2% of the surveyed patients with T1DM and 6.5% of … By HRpQCT, both trabecular and cortical compartments are abnormal at the radius and tibia in postmenopausal women with PHPT. TBS was evaluated by determining the variogram of the trabecular bone projected image, calculated as the sum of the squared gray-level differences between pixels at a specific distance and angle. Parisien M , Mellish RW , Silverberg SJ , et al. Roux JP , Wegrzyn J , Boutroy S , Bouxsein M , Hans D , Chapurlat R. Pothuaud L , Barthe N , Krieg MA , Mehsen N , Carceller P , Hans D. Rabier B , Heraud A , Grand-Lenoir C , Winzenrieth R , Hans D. Winzenrieth R , Dufour R , Pothuaud L , Hans D. Del Rio LM , Winzenrieth R , Cormier C , Di Gregorio S. Popp A , Meer S , Krieg MA , Perrelet R , Hans D , Lippuner K. Hans D , Goertzen AL , Krieg MA , Leslie WD. The Trabecular Bone Score is computed from the antero-posterior spine DXA examination file by a software (TBS iNsight) that is provided for use as a complement to a DXA analysis. Boutroy S , Vilayphiou N , Roux JP , et al. It was proposed to be easily used in everyday practice as a surrogate of bone strength. At the radius, TBS explained 25% and 21% of the variance in Tb.N and Tb.Sp, respectively, with a slight increase in the degree of variance explained by the combination of TBS with L1–L4 aBMD compared with L1–L4 aBMD alone (Table 3). Cheng X, Yuan H, Cheng J, Weng X, Xu H, Gao J, Huang M, Wáng YXJ, Wu Y, Xu W, Liu L, Liu H, Huang C, Jin Z, Tian W; Bone and Joint Group of Chinese Society of Radiology, Chinese Medical Association (CMA), Musculoskeletal Radiology Society of Chinese Medical Doctors Association, Osteoporosis Group of Chinese Orthopedic Association, Bone Density Group of Chinese Society of Imaging Technology, CMA*. It is an index of bone microarchitecture that provides skeletal information complementary to that obtained from standard bone mineral density (BMD) measurement. After this observation, TBS was derived from DXA images of lumbar vertebrae, and significant correlations between trabecular indices by μCT and TBS were confirmed (13, 14). Descriptive statistics are expressed as means ± SEM. Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. TBS was correlated with whole bone stiffness and all HRpQCT indices, except for trabecular thickness and trabecular stiffness at the radius. Krieg MA , Aubry-Rozier B , Hans D , Leslie WD. Our aim was to assess TBS in children with inflammatory bowel diseases and to evaluate correlations with clinical, laboratory and densitometric variables. Trabecular bone score (TBS), a gray‐level texture measure derived from lumbar spine (LS) dual‐energy X‐ray absorptiometry (DXA) images, improves fracture risk prediction beyond that provided by the combination of bone mineral density (BMD) by DXA and clinical risk factors. It is a textural index that evaluates pixel gray-level variations in the lumbar spine DXA (dual energy X-ray absorptiometry) image. Bone mineral density (BMD) was taken as a quantitative assessment and trabecular bone score (TBS) was used as qualitatively parameter.). Despite the fact that TBS estimates trabecular microarchitecture, our results also revealed positive correlations between TBS and Ct.vBMD and Ct.Th at the radius and tibia. Although the prevalence of osteoporosis at any site was 50%, the L1–L4 T-score by DXA was well above the WHO osteoporosis threshold (T-score ≤2.5) in the vast majority of subjects. At the tibia, TBS was a poor predictor of the variance in HRpQCT measurements of trabecular microarchitecture. Trabecular Bone Score (TBS®) by Medimaps is a fracture risk predictor using DEXA as a source. Romagnoli E , Cipriani C , Nofroni I , et al. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The Trabecular Bone Score is a newly developed test of your bone structure that is complementary to standard bone density testing. Linear regression analyses, without and with adjustment for weight, were applied to estimate the variability in HRpQCT and biomechanical parameters when TBS, aBMD at the lumbar spine, or the combination of both was used as the explanatory variable. Baseline Characteristics of 22 Subjects With PHPT. . The reference ranges in premenopausal women for OC, BSAP, and CTX were, respectively, 8.4 to 33.9 ng/mL, 11.6 to 29.6 U/L, and 0.112 to 0.738 ng/mL. Front. Endocrinol Metab Clin North Am. Yu N , Donnan PT , Flynn RW , Murphy MJ , Smith D , Rudman A , Leese GP. Whereas HRpQCT has added a dimension of insight not previously seen with regard to trabecular bone in PHPT, HRpQCT is not widely available and remains so far a research tool. The aim of this study was to estimate the reference values of TBS in both genders among the Iranian population to evaluate osteoporotic fractures in the future. Because trabecular microstructure can differ significantly among different anatomical sites, it is possible that these weak relationships are explained by the comparison of a method that estimates trabecular microarchitecture at the lumbar spine (TBS) with a technology that measures trabecular microstructure and stiffness at the radius and tibia (HRpQCT). As shown in Table 2, TBS was significantly correlated with all radius HRpQCT and biomechanical measurements except total area, Tb.Th, and trabecular stiffness. The results of this study show, for the first time, significant correlations between TBS and HRpQCT measurements of volumetric densities, skeletal microarchitecture, and bone stiffness at the radius and tibia in a group of postmenopausal women with PHPT. Among the 29 women screened, 1 was excluded because of her premenopausal status and 6 were excluded because of a history of bisphosphonate use within 2 years before study. 2017 Jul-Sep;20(3):334-345. doi: 10.1016/j.jocd.2017.06.019. Even though these studies did not involve patients with PHPT, our findings suggest that low TBS may be related with decreased bone stiffness, and consequently, fracture risk, also in PHPT. The correlation of TBS with HRpQCT indices, mechanical parameters, and DXA measurements was assessed by the Pearson correlation test. HHS The inter- and intra-assay coefficients are <7% and <5%, respectively. Liu XS , Zhang XH , Sekhon KK , et al. INTRODUCTION:Trabecular bone score (TBS) is a textural index that evaluates bone microarchitecture of the lumbar spine.